Arterial compliance and distensibility in spontaneously hypertensive rats
Details
Serval ID
serval:BIB_16EB66F6A92C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Arterial compliance and distensibility in spontaneously hypertensive rats
Journal
Journal of Hypertension. Supplement
ISSN
0952-1178 (Print)
Publication state
Published
Issued date
08/1992
Volume
10
Number
6
Pages
S79-81
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
AIM: These studies were undertaken in intact spontaneously hypertensive rats (SHR) to assess whether the elastic behavior of conduit arteries changes as a function of age. METHODS: We studied 16-week-old (n = 10) and 36-week-old (n = 10) SHR under fluothane anesthesia. Diameter-, compliance-, and distensibility-pressure curves were established non-invasively for the carotid artery by means of a high-precision ultrasonic echo-tracking device. Intra-arterial pressure was monitored simultaneously in the contralateral carotid artery. RESULTS: Mean blood pressure was 197 +/- 6 and 185 +/- 3 mmHg (mean +/- SEM) in the younger and older SHR, respectively. No significant difference was observed between the two groups of rats in the diameter-, compliance- and distensibility-pressure curves. CONCLUSIONS: These results suggest that the elastic behavior of elastic arteries is not necessarily altered with aging in rats with genetic hypertension.
Keywords
Age Factors
Animals
Blood Pressure
Carotid Artery, External/anatomy & histology/*physiology/ultrasonography
*Compliance
Rats
Rats, Inbred SHR/*physiology
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 12:46