A correlated frailty model with long-term survivors for estimating the heritability of breast cancer

Details

Serval ID
serval:BIB_1680EE613B9D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A correlated frailty model with long-term survivors for estimating the heritability of breast cancer
Journal
Statistics in Medicine
Author(s)
Locatelli Isabella, Rosina Alessandro, Lichtenstein Paul, Yashin Anatoli I.
ISSN
0277-6715
Publication state
Published
Issued date
09/2007
Peer-reviewed
Oui
Volume
26
Number
20
Pages
3722-34
Language
english
Notes
SAPHIRID:59878 --- Old month value: Sept
Abstract
The aim of this study is to investigate the role of genetics and environment in susceptibility to breast cancer (frailty). An interdisciplinary approach was adopted, combining a correlated frailty-mixture model with genetic equations, allowing for decomposition of the frailty variance into genetic and environmental components. In addition, the possibility that a fraction of the population under study is 'immune' to the disease is evaluated, and changes in heritability estimates introducing a fraction of non-susceptible individuals are determined. The methodology is applied to breast cancer data from the Swedish Twin Registry, including information about all female monozygotic and dizygotic twin pairs born in Sweden between 1886 and 1967. The inferential problem is solved in a Bayesian framework and the numerical work is carried out using Markov chain Monte Carlo (MCMC) methods. [Ed.]
Keywords
Breast Neoplasms , Disease Susceptibility , Models, Statistical , Survivors
Pubmed
Web of science
Create date
04/03/2008 14:58
Last modification date
20/08/2019 12:46
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