Brain glucose metabolism and dopamine D2 receptor analysis in a patient with hemiparkinsonism-hemiatrophy syndrome.

Details

Serval ID
serval:BIB_16784EA9F942
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Brain glucose metabolism and dopamine D2 receptor analysis in a patient with hemiparkinsonism-hemiatrophy syndrome.
Journal
Movement Disorders
Author(s)
Przedborski S., Goldman S., Levivier M., Giladi N., Bidaut L.M., Hildebrand J., Stanus E., Labar D., Luxen A.
ISSN
0885-3185 (Print)
ISSN-L
0885-3185
Publication state
Published
Issued date
1993
Peer-reviewed
Oui
Volume
8
Number
3
Pages
391-395
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
We report findings on brain glucose metabolism and dopamine D2 receptors generated by positron emission tomography (PET) in a 67-year-old woman with right hemiparkinsonism-hemiatrophy syndrome (HP-HA). PET with [18F]-fluorodeoxyglucose (FDG) showed marked glucose metabolism asymmetry. There were significant reductions in glucose uptake at the level of the basal ganglia and, to lesser extent, in the fronto-parietal cortex contralateral to the clinically involved side. These changes were different from those found in a patient with hemi-Parkinson's disease who was scanned under similar conditions. Because the patient with HP-HA had only minimal response to levodopa therapy, we evaluated post-synaptic dopaminergic structures using PET with [18F]-fluoroethylspiperone (FESP). No striatal binding asymmetry was found in FESP/PET, which suggests a sparing of striatal dopamine D2 receptors. The changes in FDG uptake which we found were in brain areas relevant to the clinical features of HP-HA syndrome. In addition, our study provides evidence that FDG/PET may help to differentiate HP-HA syndrome from hemi-Parkinson's disease. In most instances, since HP-HA is associated with a more benign clinical course than Parkinson's disease, this distinction is of clinical important.
Keywords
Aged, Basal Ganglia/metabolism, Basal Ganglia/radionuclide imaging, Brain/metabolism, Brain/radionuclide imaging, Corpus Striatum/metabolism, Corpus Striatum/radionuclide imaging, Diagnosis, Differential, Female, Functional Laterality, Glucose/metabolism, Humans, Parkinson Disease/diagnosis, Parkinson Disease/metabolism, Receptors, Dopamine D2/metabolism, Spiperone/analogs & derivatives, Spiperone/diagnostic use, Tomography, Emission-Computed
Pubmed
Web of science
Create date
20/01/2008 17:35
Last modification date
20/08/2019 12:46
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