Genome-wide analysis of retroviral DNA integration

Details

Serval ID
serval:BIB_16714CE5A160
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Genome-wide analysis of retroviral DNA integration
Journal
Nature Reviews Microbiology
Author(s)
Bushman  F., Lewinski  M., Ciuffi  A., Barr  S., Leipzig  J., Hannenhalli  S., Hoffmann  C.
ISSN
1740-1526
Publication state
Published
Issued date
11/2005
Peer-reviewed
Oui
Volume
3
Number
11
Pages
848-58
Notes
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Nov
Abstract
Retroviral vectors are often used to introduce therapeutic sequences into patients' cells. In recent years, gene therapy with retroviral vectors has had impressive therapeutic successes, but has also resulted in three cases of leukaemia caused by insertional mutagenesis, which has focused attention on the molecular determinants of retroviral-integration target-site selection. Here, we review retroviral DNA integration, with emphasis on recent genome-wide studies of targeting and on the status of efforts to modulate target-site selection.
Keywords
Animals Avian Sarcoma Viruses/genetics DNA, Complementary/genetics Gene Therapy *Genetic Vectors Humans Leukemia Virus, Murine/genetics Proviruses/genetics Retroviridae/*genetics Species Specificity *Virus Integration
Pubmed
Web of science
Create date
22/02/2008 14:45
Last modification date
20/08/2019 12:46
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