Thermogenic effect of amrinone in healthy men.

Details

Serval ID
serval:BIB_166CC613F423
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Thermogenic effect of amrinone in healthy men.
Journal
Critical Care Medicine
Author(s)
Ruttimann Y., Chioléro R., Revelly J.P., Jeanprêtre N., Schutz Y.
ISSN
0090-3493 (Print)
ISSN-L
0090-3493
Publication state
Published
Issued date
1994
Volume
22
Number
8
Pages
1235-1240
Language
english
Abstract
OBJECTIVES: The thermogenic effect of amrinone is unknown and its utilization in patients with severe cardiac failure could potentially increase oxygen requirements and therefore aggravate oxygen debt. Consequently, the present study was undertaken to assess the thermogenic response to amrinone at three different plasma concentrations under controlled conditions and to analyze amrinone's effects on various biochemical variables.
DESIGN: A prospective, unblinded, controlled study. The initial control period was followed by three sequential, experimental treatments.
SUBJECTS: Ten young, healthy, male volunteers with normal body weight.
INTERVENTIONS: Three experimental periods. Amrinone was administered intravenously in progressive doses: a) 0.5 mg/kg followed by 5 micrograms/kg/min; b) 0.5 mg/kg followed by 10 micrograms/kg/min; and c) 1.0 mg/kg followed by 10 micrograms/kg/min.
MEASUREMENTS AND MAIN RESULTS: Oxygen consumption (VO2) and CO2 production were continuously measured by means of a computerized indirect calorimeter. At the highest dose, amrinone produced a slight and significant (p < .01) increase in VO2 and in resting metabolic rate (+4.5% and +3.7%, respectively), while no change in CO2 production or in respiratory quotient occurred throughout the study. At the medium and high doses, amrinone increased plasma free fatty acid concentrations by 38% and 53%, respectively (p < .05). No variation in plasma glucose, lactate, insulin, norepinephrine, or epinephrine concentrations was observed during the study.
CONCLUSIONS: Amrinone administered intravenously at therapeutic doses has minimal thermogenic and metabolic effects in humans without cardiac failure.
Keywords
Adult, Amrinone/blood, Amrinone/pharmacology, Basal Metabolism/drug effects, Body Temperature Regulation/drug effects, Calorimetry, Indirect, Carbon Dioxide/analysis, Energy Metabolism/drug effects, Hemodynamics/drug effects, Humans, Infusions, Intravenous, Injections, Intravenous, Male, Oxygen Consumption/drug effects, Prospective Studies
Pubmed
Web of science
Create date
21/01/2008 13:07
Last modification date
20/08/2019 12:46
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