Peroxisome proliferator-activated receptors: insight into multiple cellular functions.

Details

Serval ID
serval:BIB_16519
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Peroxisome proliferator-activated receptors: insight into multiple cellular functions.
Journal
Mutation Research
Author(s)
Escher P., Wahli W.
ISSN
0027-5107[print], 0027-5107[linking]
Publication state
Published
Issued date
2000
Volume
448
Number
2
Pages
121-138
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Peroxisome proliferator-activated receptors, PPARs, (NR1C) are nuclear hormone receptors implicated in energy homeostasis. Upon activation, these ligand-inducible transcription factors stimulate gene expression by binding to the promoter of target genes. The different structural domains of PPARs are presented in terms of activation mechanisms, namely ligand binding, phosphorylation, and cofactor interaction. The specificity of ligands, such as fatty acids, eicosanoids, fibrates and thiazolidinediones (TZD), is described for each of the three PPAR isotypes, alpha (NR1C1), beta (NR1C2) and gamma (NR1C3), so as the differential tissue distribution of these isotypes. Finally, general and specific functions of the PPAR isotypes are discussed, namely their implication in the control of inflammatory responses, cell proliferation and differentiation, the roles of PPARalpha in fatty acid catabolism and of PPARgamma in adipogenesis.
Keywords
Animals, Humans, Ligands, Nuclear Proteins/chemistry, Nuclear Proteins/genetics, Peroxisome Proliferators/metabolism, Receptors, Cell Surface/chemistry, Receptors, Cell Surface/genetics, Receptors, Cytoplasmic and Nuclear/chemistry, Receptors, Cytoplasmic and Nuclear/genetics, Tissue Distribution, Transcription Factors/chemistry, Transcription Factors/genetics
Pubmed
Web of science
Create date
19/11/2007 12:09
Last modification date
20/08/2019 12:45
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