Rheumatoid arthritis after 9 years of human immunodeficiency virus infection: possible contribution of tritherapy.

Details

Serval ID
serval:BIB_162DBFDE4D3C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Rheumatoid arthritis after 9 years of human immunodeficiency virus infection: possible contribution of tritherapy.
Journal
The Journal of rheumatology
Author(s)
Wegrzyn J., Livrozet J.M., Touraine J.L., Miossec P.
ISSN
0315-162X (Print)
ISSN-L
0315-162X
Publication state
Published
Issued date
10/2002
Peer-reviewed
Oui
Volume
29
Number
10
Pages
2232-2234
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Infection by human immunodeficiency virus (HIV) may affect joints in different ways. It usually increases the severity of reactive arthritis. Conversely, when rheumatoid arthritis (RA) is seen in association with HIV infection, remission of RA has been observed in some cases. We describe a patient who developed 3 successive forms of joint manifestations: early HIV related arthralgias followed by drug related arthritis, and more recently by typical RA. The first signs of joint manifestations started one year after HIV seroconversion and resolved when antiviral treatment with AZT was started. The second episode ended when lamivudine dosage was reduced. Finally, after 9 years of infection, the diagnosis of seropositive RA was made in this HLA-DR1 positive patient. The symptoms started when the immune status reached normal CD4 T cell levels, in response to antiviral tritherapy. This observation indicates the complex effect of HIV on joint inflammation.
Keywords
Adult, Anti-HIV Agents/therapeutic use, Antiretroviral Therapy, Highly Active/adverse effects, Arthritis, Reactive/drug therapy, Arthritis, Reactive/etiology, Arthritis, Reactive/immunology, HIV/isolation & purification, HIV/pathogenicity, HIV Infections/complications, HIV Infections/drug therapy, HIV Infections/immunology, Humans, Immunocompromised Host, Lamivudine/administration & dosage, Male, Saquinavir/administration & dosage, Stavudine/administration & dosage, Treatment Outcome
Pubmed
Web of science
Create date
17/01/2020 8:57
Last modification date
18/01/2020 7:26
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