Mineralocorticoid escape in man: role of renal prostaglandins

Details

Serval ID
serval:BIB_16068CEA3A77
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mineralocorticoid escape in man: role of renal prostaglandins
Journal
Acta Endocrinologica
Author(s)
Durr  J., Favre  L., Gaillard  R., Riondel  A. M., Vallotton  M. B.
ISSN
0001-5598 (Print)
Publication state
Published
Issued date
03/1982
Volume
99
Number
3
Pages
474-80
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
The role of renal prostaglandins (PGE2 and PGF2 alpha) and kallikrein in the renal escape from excess mineralocorticoid has been evaluated in 10 normal volunteers on a high sodium diet. Escape from 9-alpha-fluorohydrocortisone (9-alpha-FF) administered for 12 days (0.6 mg daily) occurred within 4-5 days when 345 +/- 50 mmol sodium had accumulated. Indomethacin, a cyclooxygenase inhibitor, was then administered for 3 days while maintaining 9-alpha-FF. This was followed by a further cumulative gain of 105 +/- 28 mmol sodium after which escape resumed. Potassium balance remained negative throughout the study. Both PGE2 and PGF2 alpha excretion increased significantly under 9-alpha-FF from respective control values of 220 +/- 50 and 818 +/- 86 ng/24 h. to 610 +/- 317 and 1213 +/- 132 ng/24 h at the time of escape. Concomitantly urinary kallikrein increased from 1.1 +/- 0.2 to 2.5 +/- 0.3 units/24 h. Creatinine clearance increased from a mean baseline value of 111 +/- 4 to 123 +/- 4 ml/min during the same period. Indomethacin produced an inhibition of prostaglandin excretion without significant alteration of kallikrein excretion. Overall these results and particularly the transient sodium retention induced by indomethacin at the time of mineralocorticoid escape, suggest that prostaglandins may contribute to the escape phenomenon, whereas the role of kallikrein does not appear to be determinant.
Keywords
Adult Aldosterone/urine Diet Dinoprost Dinoprostone Fludrocortisone/physiology Humans Indomethacin/pharmacology Kallikreins/physiology Kidney/*physiology Male Mineralocorticoids/*physiology Potassium/metabolism Prostaglandins E/*physiology Prostaglandins F/*physiology Renin/blood Sodium/*metabolism Sodium Chloride/administration & dosage *Water-Electrolyte Balance/drug effects
Pubmed
Web of science
Create date
15/02/2008 16:58
Last modification date
20/08/2019 12:45
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