Comparison of 18F-FDG and 11C-methionine for PET-guided stereotactic brain biopsy of gliomas.

Details

Serval ID
serval:BIB_15F612EC02B5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of 18F-FDG and 11C-methionine for PET-guided stereotactic brain biopsy of gliomas.
Journal
Journal of Nuclear Medicine
Author(s)
Pirotte B., Goldman S., Massager N., David P., Wikler D., Vandesteene A., Salmon I., Brotchi J., Levivier M.
ISSN
0161-5505 (Print)
ISSN-L
0161-5505
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
45
Number
8
Pages
1293-1298
Language
english
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Validation Studies Publication Status: ppublish
Abstract
We compared the contributions of the labeled tracers (11)C-methionine (Met) and (18)F-FDG for PET-guided stereotactic biopsy of brain gliomas.
METHODS: In 32 patients with glioma, stereotactic Met PET and (18)F-FDG PET were integrated in the planning of stereotactic brain biopsy. PET images were analyzed to determine which tracer offered the best information for target definition. The stereotactic coregistration of PET images allowed accurate comparison of the level, distribution, and extent of uptake for both tracers according to tumor location and grade.
RESULTS: A histologic diagnosis was obtained for all patients. All gliomas had an area of abnormal Met uptake, and 27 showed abnormal (18)F-FDG uptake. (18)F-FDG was used for target selection when its uptake was higher in tumor than in gray matter (14 gliomas). Seven were in the basal ganglia or brain stem. Met was used for target selection when there was no (18)F-FDG uptake or when (18)F-FDG uptake was equivalent to that in the gray matter (18 gliomas). Thirteen were in the cortex. Sixty-one of the 70 stereotactic trajectories obtained from the 32 patients were based on PET-defined targets and had an area of abnormal Met uptake. These 61 Met-positive trajectories always yielded a diagnosis of tumor. All nondiagnostic trajectories (n = 9) were obtained in areas with no increased uptake of Met. In all patients with increased uptake of both tracers, the focus of highest Met uptake corresponded to the focus of highest (18)F-FDG uptake. However, the extent of uptake of both tracers was variable.
CONCLUSION: Distributions of highest Met and (18)F-FDG uptake are similar in brain gliomas. Because Met provides a more sensitive signal, it is the molecule of choice for single-tracer PET-guided neurosurgical procedures in gliomas.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Biopsy/methods, Brain Neoplasms/pathology, Brain Neoplasms/radionuclide imaging, Child, Child, Preschool, Female, Fluorodeoxyglucose F18/diagnostic use, Glioma/pathology, Glioma/radionuclide imaging, Humans, Male, Methionine/diagnostic use, Middle Aged, Radiopharmaceuticals/diagnostic use, Reproducibility of Results, Sensitivity and Specificity, Stereotaxic Techniques, Surgery, Computer-Assisted/methods, Tomography, Emission-Computed/methods
Pubmed
Web of science
Create date
20/01/2008 17:35
Last modification date
20/08/2019 12:45
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