Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal
Details
Serval ID
serval:BIB_15B4AA9ABD2D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal
Journal
EMBO Journal
ISSN
0261-4189 (Print)
Publication state
Published
Issued date
10/2005
Volume
24
Number
19
Pages
3504-15
Notes
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct 5
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct 5
Abstract
Neural stem cells (NSCs) in the postnatal mammalian brain self-renew and are a source of neurons and glia. To date, little is known about the molecular and cellular mechanisms regulating the maintenance and differentiation of these multipotent progenitors. We show that Jagged1 is required by mitotic cells in the subventricular zone (SVZ) and stimulates self-renewal of multipotent epidermal growth factor-dependent NSCs. Jagged1-expressing cells line the adult SVZ and are juxtaposed to Notch1-expressing cells, some of which are putative NSCs. In vitro, endogenous Jagged1 acts through Notch1 to promote NSC maintenance and multipotency. In vivo, reducing Jagged1/Notch1 signaling decreases the number of proliferating cells in the SVZ. In addition, soluble Jagged1 promotes self-renewal and neurogenic potential of multipotent neural progenitors in vitro. Our findings suggest a central role for Jagged1 in the NSC niche in the SVZ for maintaining a population of NSCs in the postnatal brain.
Keywords
Animals
Calcium-Binding Proteins/*metabolism
Cell Differentiation/*physiology
*Cell Proliferation
Epidermal Growth Factor/metabolism
Fluorescent Antibody Technique
Intercellular Signaling Peptides and Proteins
Lateral Ventricles/*cytology
Membrane Proteins/*metabolism
Mice
Multipotent Stem Cells/cytology/*metabolism
Receptor, Notch1/metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction/*physiology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:39
Last modification date
20/08/2019 12:44