Ten-year outcomes of islet transplantation in patients with type 1 diabetes: Data from the Swiss-French GRAGIL network.

Details

Serval ID
serval:BIB_15730683B2AF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ten-year outcomes of islet transplantation in patients with type 1 diabetes: Data from the Swiss-French GRAGIL network.
Journal
American journal of transplantation
Author(s)
Lablanche S., Borot S., Wojtusciszyn A., Skaare K., Penfornis A., Malvezzi P., Badet L., Thivolet C., Morelon E., Buron F., Renard E., Tauveron I., Villard O., Munch M., Sommacal S., Clouaire L., Jacquet M., Gonsaud L., Camillo-Brault C., Colin C., Bosson J.L., Bosco D., Berney T., Kessler L., Benhamou P.Y.
Working group(s)
GRAGIL Network
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
To describe the 10-year outcomes of islet transplantation within the Swiss-French GRAGIL Network, in patients with type 1 diabetes experiencing high glucose variability associated with severe hypoglycemia and/or with functional kidney graft. We conducted a retrospective analysis of all subjects transplanted in the GRAGIL-1c and GARGIL-2 islet transplantation trials and analyzed components of metabolic control, graft function and safety outcomes over the 10-year period of follow-up. Forty-four patients were included between September 2003 and April 2010. Thirty-one patients completed a 10-year follow-up. Ten years after islet transplantation, median HbA1c was 7.2% (6.2-8.0) (55 mmol/mol [44-64]) versus 8.0% (7.1-9.1) (64 mmol/mol [54-76]) before transplantation (p < .001). Seventeen of 23 (73.9%) recipients were free of severe hypoglycemia, 1/21 patients (4.8%) was insulin-independent and median C-peptide was 0.6 ng/ml (0.2-1.2). Insulin requirements (UI/kg/day) were 0.3 (0.1-0.5) versus 0.5 (0.4-0.6) before transplantation (p < .001). Median (IQR) β-score was 1 (0-4) (p < .05 when comparing with pre-transplantation values) and 51.9% recipients had a functional islet graft at 10 years. With a 10-year follow-up in a multicentric network, islet transplantation provided sustained improvement of glycemic control and was efficient to prevent severe hypoglycemia in almost 75% of the recipients.
Keywords
clinical research/practice, diabetes: type 1, endocrinology/diabetology, islets of Langerhans
Pubmed
Web of science
Create date
24/05/2021 14:02
Last modification date
18/09/2021 6:38
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