Structure of replicating herpes simplex virus DNA

Details

Serval ID
serval:BIB_153588F7BBC5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Structure of replicating herpes simplex virus DNA
Journal
Journal of Virology
Author(s)
Jongeneel  C. V., Bachenheimer  S. L.
ISSN
0022-538X (Print)
Publication state
Published
Issued date
08/1981
Volume
39
Number
2
Pages
656-60
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Abstract
We have investigated the molecular anatomy of the herpes simplex virus replicative intermediates by cleavage with the restriction endonuclease BglII. We find that in populations of multiply infected cells, pulse-labeled replicating herpes simplex virus DNA contains at least two and probably all four sequence isomers. Also, it contains no detectable termini. In pulse-chase experiments, we show that endless replicative intermediates are the precursors to virion DNA and that maturation is a relatively slow process. The results are discussed in terms of their significance to possible models of herpes simplex virus DNA replication.
Keywords
*Bacterial Proteins Base Sequence *DNA Replication DNA Restriction Enzymes DNA, Viral/*analysis *Deoxyribonucleases, Type II Site-Specific Simplexvirus/analysis/*metabolism *Virus Replication
Pubmed
Web of science
Create date
24/01/2008 15:40
Last modification date
20/08/2019 12:44
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