Shorter survival of SDF1-3'A/3'A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection

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Serval ID
serval:BIB_15251431BF3D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Shorter survival of SDF1-3'A/3'A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection
Journal
Journal of Infectious Diseases
Author(s)
Brambilla  A., Villa  C., Rizzardi  G., Veglia  F., Ghezzi  S., Lazzarin  A., Cusini  M., Muratori  S., Santagostino  E., Gringeri  A., Louie  L. G., Sheppard  H. W., Poli  G., Michael  N. L., Pantaleo  G., Vicenzi  E.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
07/2000
Volume
182
Number
1
Pages
311-5
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul
Abstract
The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3'A/3'A genotype and accelerated disease progression was evident among seroconverters (n=319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4(+) T cell counts <200 was observed. The relative hazards for SDF1-3'A/3'A homozygotes, compared with heterozygotes and wild-type homozygotes were 2.16 (P=.0047), for time from diagnosis according to the 1993 Centers for Disease Control and Prevention AIDS case definition (AIDS-'93) to death, and 3.43 (P=.0001), for time from CD4(+) T cells <200 to death. Because no difference in survival was observed after diagnosis according to AIDS-'87, the association of the SDF1-3'A/3'A genotype with the accelerated progression of late-stage HIV-1 disease appears to be explained for the most part by the loss of CD4(+) T lymphocytes.
Keywords
Acquired Immunodeficiency Syndrome/diagnosis/*genetics/immunology/mortality Adult CD4 Lymphocyte Count Chemokines, CXC/*genetics/immunology Cohort Studies Cresols Disease Progression Drug Combinations Formaldehyde Genetic Markers Genotype *Hiv-1 Humans Male Polymorphism, Genetic Prognosis Resorcinols Survival Rate Viremia/etiology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 15:14
Last modification date
01/10/2019 6:16
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