Cholestérol et risque d'accident vasculaire cérébral: un rôle pour les statines [Cholesterol and stroke risk: a role for statins?]

Details

Serval ID
serval:BIB_15244
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cholestérol et risque d'accident vasculaire cérébral: un rôle pour les statines [Cholesterol and stroke risk: a role for statins?]
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Devuyst G., Bogousslavsky J.
ISSN
0036-7672
Publication state
Published
Issued date
2000
Volume
130
Number
33
Pages
1157-1163
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Abstract
Atherosclerosis is the most common cause of vascular diseases, but the relevance of cholesterol has only been definitely associated with coronary artery disease and peripheral vascular disease. In comparison, the role of cholesterol in stroke is, while a tempting assumption, subject to controversy in the literature. The crucial question--is cholesterol a risk factor for stroke?--remains open. Recent trials with statin drugs, such as 4 S, CARE, LIPID and WOSCOP, have created a new wave of enthusiasm by showing decreased risk of stroke in the statin-treated patients. However, these trials are most often designed for patients with a known history of coronary artery disease. In contrast, studies investigating the impact of statins in the secondary prevention of stroke are still lacking. Moreover, the beneficial effects of statins on clinical events may involve non-cholesterol mechanisms. In regard to stroke prevention, there is no absolute evidence to recommend the use of statin drug therapy.
Keywords
Anticholesteremic Agents/classification, Anticholesteremic Agents/therapeutic use, Arteriosclerosis/complications, Arteriosclerosis/drug therapy, Cholesterol, Coronary Disease/complications, Coronary Disease/drug therapy, Humans, Hypercholesterolemia/complications, Hypercholesterolemia/drug therapy, Risk Factors, Stroke/epidemiology, Stroke/etiology
Pubmed
Web of science
Create date
19/11/2007 12:08
Last modification date
20/08/2019 12:44
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