Lactulose and renal failure

Details

Serval ID
serval:BIB_1512D4156675
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Lactulose and renal failure
Journal
Scandinavian Journal of Gastroenterology. Supplement
Author(s)
Vogt  B., Frey  F. J.
ISSN
0085-5928 (Print)
Publication state
Published
Issued date
1997
Volume
222
Pages
100-1
Notes
Journal Article
Review
Abstract
The introduction of lactulose as a new therapeutic agent for treatment of hepatic encephalopathy was a major breakthrough in this field. It was hypothesized that lactulose might prevent postoperative renal impairment after biliary surgery in patients with obstructive jaundice. The presumable mechanism purported was the diminished endotoxinemia by lactulose. Unfortunately, such a reno-protective effect has not been shown conclusively until now in clinical studies. In chronic renal failure lactulose is known to promote fecal excretion of water, sodium, potassium, amonium, urea, creatinine and protons. Thus, lactulose could be useful for the treatment of chronic renal failure. However, compliance to the therapy represents a major problem.
Keywords
Animals Cholestasis/surgery Gastrointestinal Agents/*therapeutic use Humans Kidney Failure, Acute/*drug therapy Kidney Failure, Chronic/*drug therapy Lactulose/*therapeutic use Postoperative Complications/prevention & control
Pubmed
Create date
25/01/2008 13:03
Last modification date
20/08/2019 12:44
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