Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescents.

Details

Serval ID
serval:BIB_1510A252FF09
Type
Article: article from journal or magazin.
Collection
Publications
Title
Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescents.
Journal
Brain and behavior
Author(s)
Liverani M.C., Freitas LGA, Siffredi V., Mikneviciute G., Martuzzi R., Meskaldij D.E., Borradori Tolsa C., Ha-Vinh Leuchter R., Schnider A., Van De Ville D., Hüppi P.S.
ISSN
2162-3279 (Electronic)
Publication state
Published
Issued date
04/2020
Peer-reviewed
Oui
Volume
10
Number
4
Pages
e01552
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Orbitofrontal reality filtering (ORFi) is a memory mechanism that distinguishes whether a thought is relevant to present reality or not. In adults, it is mediated by the orbitofrontal cortex (OFC). This region is still not fully developed in preteenagers, but ORFi is already active from age 7. Here, we probe the neural correlates of ORFi in early adolescents, hypothesizing that OFC mediates the sense of reality in this population.
Functional magnetic resonance images (fMRI) were acquired in 22 early adolescents during a task composed of two runs: run 1 measuring recognition capacity; run 2 measuring ORFi; each containing two types of images (conditions): distractors (D: images seen for the first time in the current run) and targets (T: images seen for the second time in the current run). Group region of interest (ROI) analysis was performed in a flexible factorial design with two factors (run and condition) using SPM12.
We found significant main effects for the experimental run and condition. The bilateral OFC activation was higher during ORFi than during the first run. Additionally, the OFC was more active while processing distractors than targets.
These results confirm, for the first time, the role of OFC in reality filtering in early adolescents.
Keywords
Adolescent, Child, Female, Humans, Magnetic Resonance Imaging, Male, Memory/physiology, Photic Stimulation, Prefrontal Cortex/diagnostic imaging, Prefrontal Cortex/physiology, Recognition, Psychology/physiology, early adolescents, fMRI, memory, orbitofrontal cortex, orbitofrontal reality filtering
Pubmed
Web of science
Open Access
Yes
Create date
23/11/2023 11:46
Last modification date
10/01/2024 17:36
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