Crigler-Najjar syndrome type 1 (CNS1) is characterized by a severe unconjugated hyperbilirubinemia from birth. Intensive blue-light phototherapy is the standard method for management; however, it imposes severe restrictions on the child and their family's lifestyle. We describe here the use of a novel sit-up phototherapy unit in a child with CNS1. The unit allowed a 50% reduction in phototherapy time while maintaining efficacy, thus enabling the child to attend school.