Ets-1 maintains IL-7 receptor expression in peripheral T cells.

Details

Serval ID
serval:BIB_14DFAC8DF43F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Ets-1 maintains IL-7 receptor expression in peripheral T cells.
Journal
Journal of immunology
Author(s)
Grenningloh R., Tai T.S., Frahm N., Hongo T.C., Chicoine A.T., Brander C., Kaufmann D.E., Ho I.C.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Publication state
Published
Issued date
15/01/2011
Peer-reviewed
Oui
Volume
186
Number
2
Pages
969-976
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The expression of CD127, the IL-7-binding subunit of the IL-7 R, is tightly regulated during the development and activation of T cells and is reduced during chronic viral infection. However, the molecular mechanism regulating the dynamic expression of CD127 is still poorly understood. In this study, we report that the transcription factor Ets-1 is required for maintaining the expression of CD127 in murine peripheral T cells. Ets-1 binds to and activates the CD127 promoter, and its absence leads to reduced CD127 expression, attenuated IL-7 signaling, and impaired IL-7-dependent homeostatic proliferation of T cells. The expression of CD127 and Ets-1 is strongly correlated in human T cells. Both CD127 and Ets-1 expression are decreased in CD8(+) T cells during HIV infection. In addition, HIV-associated loss of CD127 is only observed in Ets-1(low) effector memory and central memory but not in Ets-1(high) naive CD8(+) T cells. Taken together, our data identify Ets-1 as a critical regulator of CD127 expression in T cells.
Keywords
Animals, Cells, Cultured, Female, HIV-1/immunology, Humans, Interleukin-7/biosynthesis, Interleukin-7/genetics, Interleukin-7 Receptor alpha Subunit/biosynthesis, Interleukin-7 Receptor alpha Subunit/genetics, Interleukin-7 Receptor alpha Subunit/metabolism, Male, Mice, Mice, Knockout, Promoter Regions, Genetic/immunology, Protein Binding/immunology, Proto-Oncogene Protein c-ets-1/deficiency, Proto-Oncogene Protein c-ets-1/genetics, Proto-Oncogene Protein c-ets-1/metabolism, Proto-Oncogene Protein c-ets-1/physiology, T-Lymphocyte Subsets/immunology, T-Lymphocyte Subsets/metabolism, T-Lymphocyte Subsets/virology
Pubmed
Web of science
Open Access
Yes
Create date
09/05/2023 13:00
Last modification date
29/11/2024 16:52
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