Incidence and outcome of invasive fungal diseases after allogeneic hematopoietic stem cell transplantation: A Swiss transplant cohort study.

Details

Serval ID
serval:BIB_14D606BDD623
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Incidence and outcome of invasive fungal diseases after allogeneic hematopoietic stem cell transplantation: A Swiss transplant cohort study.
Journal
Transplant infectious disease
Author(s)
Kuster S., Stampf S., Gerber B., Baettig V., Weisser M., Gerull S., Medinger M., Passweg J., Schanz U., Garzoni C., Berger C., Chalandon Y., Mueller N.J., van Delden C., Neofytos D., Khanna N.
Working group(s)
Swiss Transplant Cohort Study
Contributor(s)
Achermann R., Amico P., Aubert J.D., Banz V., Beldi G., Benden C., Binet I., Bochud P.Y., Bucher H., Carell T., Catana E., de Geest S., de Rougemont O., Dickenmann M., Duchosal M., Elkrief L., Fehr T., Ferrari-Lacraz S., Soccal G., Gaudet C., Giostra E., Golshayan D., Hadaya K., Halter J., Heim D., Hess C., Hillinger S., Hirsch H., Hofbauer G., Huynh-Do U., Immer F., Klaghofer R., Koller M., Lehmann R., Lovis C., Majno P., Manuel O., Marti H.P., Martin Y., Meylan P., Mohacsi P., Morel P., Mueller U., Mueller-McKenna H., Müller A., Müller T., Müllhaupt B., Nadal D., Pascual M., Rick J., Roosnek E., Rosselet A., Rothlin S., Ruschitzka F., Schaub S., Schnyder A., Seiler C., Steiger J., Stirnimann G., Toso C., Venetz J.P., Villard J., Wick M., Wilhelm M., Yerly P.
ISSN
1399-3062 (Electronic)
ISSN-L
1398-2273
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
20
Number
6
Pages
e12981
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Contemporary, comprehensive data on epidemiology and outcomes of invasive fungal disease (IFD) including breakthrough IFD among allogeneic hematopoietic stem cell transplantation (HSCT) recipients are scarce. We included 479 allogeneic HSCT recipients with 10 invasive candidiasis (IC) and 31 probable/proven invasive mold disease (IMD) from the Swiss Transplant Cohort Study from 01.2009 to 08.2013. Overall cumulative incidence was 2.3% for IC and 8.5% for probable/proven IMI: 6% for invasive aspergillosis (IA) and 2.5% for non-AspergillusIMI. Among 41 IFD, 46% IFD were breakthrough, with an overall incidence of 4.6%, more frequently caused by other-than-Aspergillus fumigatus molds than primary IFD (47.6% (10/21) vs 13% (3/23), P = 0.04). Twelve-week mortality among patients with IC was 20% and 58.6% for probable/proven IMD (60% IA and 54.6% non-Aspergillus). Our results reveal that breakthrough IFD represent a marked burden of probable/proven IFD postallogeneic HSCT and mortality remains above 50% in patients with probable/proven IMD, underscoring the ongoing challenges to prevent and treat IFD in these patients.
Keywords
Adult, Antibiotic Prophylaxis/adverse effects, Antibiotic Prophylaxis/methods, Antifungal Agents/adverse effects, Candida/drug effects, Candida/isolation & purification, Candida/physiology, Candidiasis, Invasive/epidemiology, Candidiasis, Invasive/microbiology, Candidiasis, Invasive/prevention & control, Drug Resistance, Fungal, Female, Hematopoietic Stem Cell Transplantation/adverse effects, Humans, Incidence, Male, Middle Aged, Prospective Studies, Switzerland, Transplantation, Homologous/adverse effects, breakthrough infections, hematopoietic stem cell transplantation, invasive fungal diseases, invasive mold disease
Pubmed
Web of science
Create date
13/02/2019 11:49
Last modification date
20/08/2019 13:43
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