In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case for Organometallic Anticancer Drugs Not Based on Ruthenium

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Version: Final published version
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Serval ID
serval:BIB_1491DA4634E2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case for Organometallic Anticancer Drugs Not Based on Ruthenium
Journal
Organometallics
Author(s)
Dorcier Antoine, Ang Wee Han, Bolaño Sandra, Gonsalvi Luca, Juillerat-Jeannerat Lucienne, Laurenczy Gàbor, Peruzzini Maurizio, Phillips Andrew D., Zanobini Fabrizio, Dyson Paul J.
ISSN
0276-7333
1520-6041
Publication state
Published
Issued date
08/2006
Peer-reviewed
Oui
Volume
25
Number
17
Pages
4090-4096
Language
english
Abstract
Reaction of the dimer [(eta(5)-C5Me5)RhCl(mu(2)-Cl)](2) with 2 or 4 equiv of the water-soluble phosphine 1,3,5-triaza-7-phosphatricyclo[3.3.1.1] decane (pta) affords [Rh(eta(5)-C5Me5)(pta)Cl-2] and [Rh(eta(5)-C5Me5)(pta)(2)Cl] Cl, respectively. Both complexes have been characterized in solution by NMR spectroscopy and in the solid state by single-crystal X-ray diffraction, the latter as the chloride and BPh4- salts. In addition, the rhodium(I) complexes [Rh(eta(5)-C5Me5)(CO)(pta)] and [Rh(eta(5)-C5H5)(pta)(2)] have been prepared lfrom [Rh(eta(5)-C5Me5)(CO)(2)] and [Rh(eta(5)-C5H5)(PPh3)(2)], respectively, by reaction with pta. An in vitro evaluation of these compounds, together with [Os(eta(6)-C10H14)(pta)Cl-2] and the well-characterized antimetastasis drug [Ru(eta(6)-C10H14)(pta)Cl-2], RAPTA-C, was undertaken using HT29 colon carcinoma, A549 lung carcinoma, and T47D breast carcinoma cells. In the HT29 cell line, the two nearest congeners to [Ru(eta(6)-C10H14)(pta)Cl-2], viz., [Rh(eta(5)-C5Me5)(pta)Cl-2] and [Os(eta(6)-C10H14)(pta)Cl-2], demonstrated very similar cytotoxicity profiles. [Rh(eta(5)-C5Me5)(pta)Cl-2] proved significantly more cytotoxic in A549 cells and [Rh(eta(5)-C5Me5)(pta)(2)Cl] Cl 3-fold more cytotoxic in T47D cells, both relative to RAPTA-C. These data suggest that the development of organometallic anticancer drugs based on the neighboring elements to ruthenium should not be overlooked
Keywords
Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry
Web of science
Create date
30/01/2008 19:10
Last modification date
01/08/2020 7:08
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