Spine dynamics and synapse remodeling during LTP and memory processes.

Details

Serval ID
serval:BIB_145A959E3636
Type
Article: article from journal or magazin.
Collection
Publications
Title
Spine dynamics and synapse remodeling during LTP and memory processes.
Journal
Progress in brain research
Author(s)
De Roo M., Klauser P. (co-first), Garcia P.M., Poglia L., Muller D.
ISSN
0079-6123 (Print)
ISSN-L
0079-6123
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
169
Pages
199-207
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
While changes in the efficacy of synaptic transmission are believed to represent the physiological bases of learning mechanisms, other recent studies have started to highlight the possibility that a structural reorganization of synaptic networks could also be involved. Morphological changes of the shape or size of dendritic spines or of the organization of postsynaptic densities have been described in several studies, as well as the growth and formation following stimulation of new protrusions. Confocal in vivo imaging experiments have further revealed that dendritic spines undergo a continuous turnover and replacement process that may vary as a function of development, but can be markedly enhanced by sensory activation or following brain damage. The implications of these new aspects of plasticity for learning and memory mechanisms are discussed.
Keywords
Animals, Dendritic Spines/physiology, Hippocampus/cytology, Long-Term Potentiation/physiology, Memory/physiology, Neuronal Plasticity/physiology, Neurons/cytology, Rats, Synapses/physiology
Pubmed
Web of science
Create date
07/02/2019 9:48
Last modification date
09/12/2019 16:08
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