Selected micronutrients and colorectal cancer. a case-control study from the canton of Vaud, Switzerland.

Details

Serval ID
serval:BIB_14321
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Selected micronutrients and colorectal cancer. a case-control study from the canton of Vaud, Switzerland.
Journal
European Journal of Cancer
Author(s)
Levi F., Pasche C., Lucchini F., La Vecchia C.
ISSN
0959-8049 (Print)
ISSN-L
0959-8049
Publication state
Published
Issued date
2000
Volume
36
Number
16
Pages
2115-2119
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
The association between dietary intake of various micronutrients and colorectal cancer risk was analysed using data from a case-control study conducted between 1992 and 1997 in the Swiss Canton of Vaud. Cases were 223 subjects (142 (64%) males, 81 (36%) females; median age 63 years) with incident, histologically confirmed colon (n=119; 53%) or rectal (n=104; 47%) cancer, and controls were 491 subjects (211 (43%) males, 280 (57%) females; median age 58 years; range 27-74) admitted to the same university hospital for a wide spectrum of acute non-neoplastic conditions, unrelated to long-term modifications of diet. Dietary habits were investigated using a validated food frequency questionnaire (FFQ). Odds ratios (OR) were obtained after allowance for age, sex, education, smoking, alcohol, body mass index, physical activity, and total energy and fibre intake. No significant association was observed for calcium, retinol, folate, vitamin D or E. The risk of colorectal cancer was directly associated with measures of iron intake (OR=2.43 for the highest tertile, 95% confidence interval (CI): 1.2-5.1) and inversely associated with vitamin C (OR=0.45; 95% CI: 0.3-0.8), and non-significantly with total carotenoids (OR=0.66, 95% CI: 0.4-1.1). Among various individual carotenoids considered, inverse associations were observed for alpha-carotene, beta-carotene and lutein/zeaxanthin. These findings were consistent across the strata of gender and age, and support the hypothesis that selected micronutrients have a favourable effect on colorectal carcinogenesis.
Keywords
Adult, Aged, Case-Control Studies, Colorectal Neoplasms/epidemiology, Colorectal Neoplasms/etiology, Female, Humans, Incidence, Male, Micronutrients, Middle Aged, Odds Ratio, Regression Analysis, Risk Factors
Pubmed
Web of science
Create date
19/11/2007 12:06
Last modification date
20/08/2019 12:42
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