Novel testis germ cell-specific transcript of the CREB gene contains an alternatively spliced exon with multiple in-frame stop codons.

Details

Serval ID
serval:BIB_142ED3ABC265
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Novel testis germ cell-specific transcript of the CREB gene contains an alternatively spliced exon with multiple in-frame stop codons.
Journal
Endocrinology
Author(s)
Waeber G., Habener J.F.
ISSN
0013-7227
Publication state
Published
Issued date
1992
Peer-reviewed
Oui
Volume
131
Number
4
Pages
2010-5
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. - Publication Status: ppublish
Abstract
The gene encoding the cAMP-responsive transcription factor CREB consists of multiple small exons some of which undergo alternative RNA splicing. We describe the finding of a novel transcript of the CREB gene expressed at high levels in the germ cells of the rat testis. The transcript contains an alternatively spliced exon inserted within the sequence encoding the transcriptional transactivation domain of CREB and this exon contains multiple in-frame stop codons. Furthermore, the exon is conserved in both rat and human genes (75% nucleotide identity). Although the function(s) of this RNA or the truncated CREB protein predicted to result from the translation of this unusual transcript is unknown, the high level of expression in the testicular germ cells and remarkable conservation of sequences in rat and human suggests that it may have a unique biological function in these cells.
Keywords
Animals, Codon, Cyclic AMP Response Element-Binding Protein, Exons, Germ Cells, Male, Molecular Sequence Data, Oligonucleotide Probes, RNA Splicing, Rats, Reading Frames, Testis, Transcription, Genetic
Pubmed
Web of science
Create date
25/01/2008 14:10
Last modification date
20/08/2019 12:42
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