BACKGROUNDS. Cough is an essential protective reflex of the respiratory tract, which is triggered by various chemical or mechanical stimuli. It can be caused by acute or chro- nic upper aerodigestive tract conditions, alone or in combination. Cough can be initia- ted voluntarily from the cortical system or as an involuntary reflex. The upper airway cough syndrome (i.e., previously post nasal drip syndrome) has been identified as the most common cause of acute and chronic cough. This syndrome can present in chronic rhinosinusitis, which is a common disease marked by an inflammation of the sinonasal mucosa. However, to our best knowledge, the association between chronic rhinosinusi- tis and cough has not been quantified yet. This paper aims to determine whether there is difference in self-reported cough between patients with chronic rhinosinusitis and the control group. METHODS. Cough was self-reported on the Likert scale with values 0–5 derived from the 22-item sino-nasal outcome test (SNOT-22). The analysis included patients with chronic rhinosinusitis and patients without chronic rhinosinusitis with the latter being the control group. RESULTS. The study included 477 patients with chronic rhi- nosinusitis and 73 controls. The median self-reported score for controls was 0 (interquartile range (IQR) 1) and 3 (IQR 3), p < 0.001 for chronic rhinosinusitis was. Even the ratio of those who cough is higher in the chronic rhinosinusitis group (23.3% vs. 72.1%), p < 0.001. This study has shown a difference in self-reported cough depending on whether chronic rhinosinusitis is present (χ2(1,N=550)=66.9, p<.00001). DISCUSSION. This study under- lines the intricate relationship between nasal symptoms in chronic rhinosinusitis and cough. Now that this relationship has been statistically confirmed, one can further que- stion which specific chronic rhinosinsusitis symptoms (from the sino nasal outcome test questionnaire) are related to cough. A symptomatic evaluation of cough in the presen- ce of chronic rhinosinusitis could be developed.