Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects

Details

Serval ID
serval:BIB_13DC5BD6BEFA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects
Journal
British Journal of Clinical Pharmacology
Author(s)
Brunner  D. B., Desponds  G., Biollaz  J., Keller  I., Ferber  F., Gavras  H., Brunner  H. R., Schelling  J. L.
ISSN
0306-5251 (Print)
Publication state
Published
Issued date
05/1981
Volume
11
Number
5
Pages
461-7
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: May
Abstract
1 MK 421 and its lysine analogue are two new inhibitors of angiotensin converting enzyme. Ten mg of both compounds were each given p.o. to 12 normotensive volunteers to determine their effect on the various components of the renin angiotensin aldosterone system. 2 Plasma converting enzyme activity decreased to very low levels within 3 to 4 h to recover only slowly over the next 72 h. Plasma angiotensin II and aldosterone also fell but returned to baseline within 24 h, whereas plasma renin activity rose reflecting the low angiotensin II levels. 3 There was a close correlation between both angiotensin II and aldosterone levels and the logarithm of plasma converting enzyme activity demonstrating that angiotensin II and aldosterone fell only when converting enzyme activity was reduced to very low levels. 4 Mean hourly urinary sodium excretion increased markedly 6 to 10 h post-drug, while blood pressure decreased slightly. Both drugs were well tolerated. 5 Thus 10 mg of MK 421 or its lysine analogue given orally are effective and long acting angiotensin converting enzyme inhibitors.
Keywords
Adult *Angiotensin-Converting Enzyme Inhibitors Blood Pressure/drug effects Dipeptides/*pharmacology Diuresis/drug effects Electrolytes/urine Enalapril Heart Rate/drug effects Humans Lisinopril Male Peptidyl-Dipeptidase A/blood Renin-Angiotensin System/*drug effects
Pubmed
Web of science
Create date
25/01/2008 10:40
Last modification date
20/08/2019 12:42
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