m<sup>6</sup>A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression.

Details

Serval ID
serval:BIB_13D2485FC275
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
m<sup>6</sup>A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression.
Journal
Trends in genetics
Author(s)
Roignant J.Y., Soller M.
ISSN
0168-9525 (Print)
ISSN-L
0168-9525
Publication state
Published
Issued date
06/2017
Peer-reviewed
Oui
Volume
33
Number
6
Pages
380-390
Language
english
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Modifications in mRNA constitute ancient mechanisms to regulate gene expression post-transcriptionally. N <sup>6</sup> -methyladenosine (m <sup>6</sup> A) is the most prominent mRNA modification, and is installed by a large methyltransferase complex (the m <sup>6</sup> A 'writer'), not only specifically bound by RNA-binding proteins (the m <sup>6</sup> A 'readers'), but also removed by demethylases (the m <sup>6</sup> A 'erasers'). m <sup>6</sup> A mRNA modifications have been linked to regulation at multiple steps in mRNA processing. In analogy to the regulation of gene expression by miRNAs, we propose that the main function of m <sup>6</sup> A is post-transcriptional fine-tuning of gene expression. In contrast to miRNA regulation, which mostly reduces gene expression, we argue that m <sup>6</sup> A provides a fast mean to post-transcriptionally maximize gene expression. Additionally, m <sup>6</sup> A appears to have a second function during developmental transitions by targeting m <sup>6</sup> A-marked transcripts for degradation.
Keywords
Adenosine/analogs & derivatives, Adenosine/genetics, Adenosine/metabolism, DNA Methylation/genetics, Epigenesis, Genetic, Gene Expression Regulation/genetics, Humans, RNA Processing, Post-Transcriptional/genetics, RNA, Messenger/genetics, RNA-Binding Proteins/genetics, Xist, alternative splicing/polyadenylation, mRNA export, mRNA stability, mRNA translation, sex lethal
Pubmed
Web of science
Create date
28/10/2019 13:46
Last modification date
29/10/2019 7:26
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