Clinical and laboratory risk factors for sickle cell retinopathy and maculopathy: a scoping review of the current evidence.

Details

Serval ID
serval:BIB_134A880402A6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Clinical and laboratory risk factors for sickle cell retinopathy and maculopathy: a scoping review of the current evidence.
Journal
Haematologica
Author(s)
Brandsen R.P., Diederen RMH, Kocabas G., Nur E., Malekzadeh A., Schlingemann R.O., Biemond B.J.
ISSN
1592-8721 (Electronic)
ISSN-L
0390-6078
Publication state
In Press
Peer-reviewed
Oui
Pages
0
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Sickle cell retinopathy (SCR) is a complication of sickle cell disease (SCD) and can drastically impair visual acuity. Screening for SCR is therefore recommended, but evidence for optimal screening frequency on an individual level is lacking. This scoping review mapped the current evidence on risk factors for SCR and sickle cell maculopathy (SCM). A literature search (in Medline(Ovid), Embase(Ovid) and Scopus) resulted in 67 included articles, which covered demographic risk factors, genetic risk factors, systemic therapy, correlations with other forms of SCD-related organ damage and hematological risk factors. SCR risk factors include older age, male sex, HbSC genotype, hemolysis and HbF% 15%) patients to ensure comprehensive yet proportionate ophthalmic care. However, to elucidate the sense and nonsense of screening, future studies are needed on the role of interventions for SCR and the long-term consequences of SCM.
Pubmed
Open Access
Yes
Create date
07/01/2025 13:05
Last modification date
09/01/2025 7:04
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