The Promise of Personalized TCR-Based Cellular Immunotherapy for Cancer Patients.

Details

Serval ID
serval:BIB_132C3057D946
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The Promise of Personalized TCR-Based Cellular Immunotherapy for Cancer Patients.
Journal
Frontiers in immunology
Author(s)
Arnaud M., Bobisse S., Chiffelle J., Harari A.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
12
Pages
701636
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Mutation-derived neoantigens are now established as attractive targets for cancer immunotherapy. The field of adoptive T cell transfer (ACT) therapy was significantly reshaped by tumor neoantigens and is now moving towards the genetic engineering of T cells with neoantigen-specific T cell receptors (TCRs). Yet, the identification of neoantigen-reactive TCRs remains challenging and the process needs to be adapted to clinical timelines. In addition, the state of recipient T cells for TCR transduction is critical and can affect TCR-ACT efficacy. Here we provide an overview of the main strategies for TCR-engineering, describe the selection and expansion of optimal carrier cells for TCR-ACT and discuss the next-generation methods for rapid identification of relevant TCR candidates for gene transfer therapy.
Keywords
T cell receptor, T cells, adoptive cell transfer, cancer immunotherapy, cell engineering, gene transfer therapy
Pubmed
Web of science
Open Access
Yes
Create date
03/09/2021 20:34
Last modification date
10/09/2021 6:38
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