Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_12B7E201A8FA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation.
Journal
Nature Communications
Author(s)
Minocha S., Valloton D., Ypsilanti A.R., Fiumelli H., Allen E.A., Yanagawa Y., Marin O., Chédotal A., Hornung J.P., Lebrand C.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
6
Pages
6887
Language
english
Abstract
Guidepost cells present at and surrounding the midline provide guidance cues that orient the growing axons through commissures. Here we show that the transcription factor Nkx2.1 known to control the specification of GABAergic interneurons also regulates the differentiation of astroglia and polydendrocytes within the mouse anterior commissure (AC). Nkx2.1-positive glia were found to originate from three germinal regions of the ventral telencephalon. Nkx2.1-derived glia were observed in and around the AC region by E14.5. Thereafter, a selective cell ablation strategy showed a synergistic role of Nkx2.1-derived cells, both GABAergic interneurons and astroglia, towards the proper formation of the AC. Finally, our results reveal that the Nkx2.1-regulated cells mediate AC axon guidance through the expression of the repellent cue, Slit2. These results bring forth interesting insights about the spatial and temporal origin of midline telencephalic glia, and highlight the importance of neurons and astroglia towards the formation of midline commissures.
Pubmed
Web of science
Open Access
Yes
Create date
10/06/2015 6:41
Last modification date
09/01/2020 6:18
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