The Lausanne Infant Crying Stress Paradigm: Validation of an Early Postpartum Stress Paradigm with Women at Low vs. High Risk of Childbirth-Related Posttraumatic Stress Disorder.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_12A072529B1D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Lausanne Infant Crying Stress Paradigm: Validation of an Early Postpartum Stress Paradigm with Women at Low vs. High Risk of Childbirth-Related Posttraumatic Stress Disorder.
Journal
Journal of personalized medicine
Author(s)
Sandoz V., Stuijfzand S., Lacroix A., Deforges C., Quillet Diop M., Ehlert U., Rubo M., Messerli-Bürgy N., Horsch A.
ISSN
2075-4426 (Print)
ISSN-L
2075-4426
Publication state
Published
Issued date
26/05/2021
Peer-reviewed
Oui
Volume
11
Number
6
Pages
472
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Stress reactivity is typically investigated in laboratory settings, which is inadequate for mothers in maternity settings. This study aimed at validating the Lausanne Infant Crying Stress Paradigm (LICSP) as a new psychosocial stress paradigm eliciting psychophysiological stress reactivity in early postpartum mothers (n = 52) and to compare stress reactivity in women at low (n = 28) vs. high risk (n = 24) of childbirth-related posttraumatic stress disorder (CB-PTSD). Stress reactivity was assessed at pre-, peri-, and post-stress levels through salivary cortisol, heart rate variability (high-frequency (HF) power, low-frequency (LF) power, and LF/HF ratio), and perceived stress via a visual analog scale. Significant time effects were observed for all stress reactivity outcomes in the total sample (all p < 0.01). When adjusting for perceived life threat for the infant during childbirth, high-risk mothers reported higher perceived stress (p < 0.001, d = 0.91) and had lower salivary cortisol release (p = 0.023, d = 0.53), lower LF/HF ratio (p < 0.001, d = 0.93), and marginally higher HF power (p = 0.07, d = 0.53) than low-risk women. In conclusion, the LICSP induces subjective stress and autonomic nervous system (ANS) reactivity in maternity settings. High-risk mothers showed higher perceived stress and altered ANS and hypothalamic-pituitary-adrenal reactivity when adjusting for infant life threat. Ultimately, the LICSP could stimulate (CB-)PTSD research.
Keywords
PTSD, TSST, childbirth, cortisol, heart rate variability, mothers, perceived stress, postpartum, stress reactivity, women
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / 32003B_172982
Create date
26/05/2021 21:39
Last modification date
10/07/2021 5:33
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