New mechanistic model for organic diisocyanate-induced respiratory disease

Details

Serval ID
serval:BIB_12983
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
New mechanistic model for organic diisocyanate-induced respiratory disease
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Savolainen H.
ISSN
0036-7672
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
129
Number
12
Pages
465-467
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
The pathophysiological mechanisms of organic diisocyanate-induced respiratory disease remain largely unknown. Some 20% of patients have specific antibodies towards diisocyanate monomers whereas even in this circumstance their presence does not correlate very well with results in clinical provocation tests. The formation of diisocyanate haptens is the trigger for the immunological reactions. However, it is known that the reactions with protein and other macromolecules may be slow and hydrolysis of the isocyanate moities to corresponding amines as catalyzed by bicarbonate is more rapid. The liberated amines, or their intermediates, probably have an important role in the activation of tissue thromboplastin activator, loss of serum antitrypsin activity, and, finally, in neurogenic inflammation. Hypothetically, susceptible individuals probably include those which are slow acetylators of exogenous amines and carries of heterozygous antitrypsin phenotypes.
Keywords
Humans, Isocyanates/toxicity, Lung Diseases/chemically induced, Lung Diseases/physiopathology, Models, Biological, Occupational Diseases/chemically induced, Occupational Diseases/physiopathology, Occupational Exposure
Pubmed
Web of science
Create date
19/11/2007 12:04
Last modification date
20/08/2019 12:40
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