Magnetic resonance imaging with gadolinium contrast agent in small deep (lacunar) cerebral infarcts.

Details

Serval ID
serval:BIB_1298103C4CD4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Magnetic resonance imaging with gadolinium contrast agent in small deep (lacunar) cerebral infarcts.
Journal
Archives of Neurology
Author(s)
Regli L., Regli F., Maeder P., Bogousslavsky J.
ISSN
0003-9942
Publication state
Published
Issued date
02/1993
Peer-reviewed
Oui
Volume
50
Number
2
Pages
175-180
Language
english
Notes
Regli, L Regli, F Maeder, P Bogousslavsky, J United states Archives of neurology Arch Neurol. 1993 Feb;50(2):175-80. --- Old month value: Feb
Abstract
OBJECTIVE--To assess gadolinium-diethylenetriamine-pentaacetic acid (Gd-DTPA) contrast-enhanced magnetic resonance (MR) imaging as an index of recent symptomatic small deep cerebral infarcts (SDCIs). DESIGN--Prospective case series. SETTINGS--Primary-care center. PATIENTS--Thirty-one consecutive patients presenting with the clinical diagnosis of SDCI in the territory of the perforators of the internal carotid artery or the vertebrobasilar system and confirmed by MR imaging. INTERVENTION--Rapid intravenous infusion of Gd-DTPA 5 to 10 minutes prior to acquisition of T1-weighted images. MAIN OUTCOME MEASURES--Precise clinicotopographic correlation on MR scans. RESULTS--Non-contrast-enhanced MR imaging allowed precise clinicotopographic correlation in five (38%) of 13 patients with SDCI symptoms in the internal carotid artery territory. After Gd-DTPA administration, precise clinicotopographic correlation improved in 11 (85%) of 13 patients. In five patients, precise correlation was possible only after Gd-DTPA enhancement. Nonenhanced MR imaging allowed precise clinicotopographic correlation in 15 (83%) of 18 patients with SDCI symptoms in the vertebrobasilar territory. After Gd-DTPA administration, we could establish precise clinicotopographic correlation in all patients with SDCIs in the vertebrobasilar territory. In three patients, precise correlation was possible only after Gd-DTPA contrast enhancement. In seven (23%) of 31 patients, Gd-DTPA failed to enhance symptomatic lesion: in five patients MR scans were performed early (less than 7 days) and in two patients later in the course (greater than 7 days). CONCLUSIONS--Although Gd-DTPA administration is unlikely to improve the sensitivity of MR images in visualizing SDCIs, it significantly improves the rate of precise clinicoanatomic correlation. All enhancing lesions showed precise clinicotopographic correlation. Enhancement may be absent in the acute phase (less than 7 days).
Keywords
Aged, Basilar Artery, Carotid Arteries, Cerebral Infarction/diagnosis, Cerebral Infarction/physiopathology, Contrast Media, Female, Gadolinium DTPA, Humans, Infusions, Intravenous, Magnetic Resonance Imaging, Male, Middle Aged, Organometallic Compounds/diagnostic use, Pentetic Acid/diagnostic use, Vertebral Artery
Pubmed
Web of science
Create date
11/04/2008 8:23
Last modification date
20/08/2019 12:40
Usage data