Rat model for renal effects of 2-alkoxyalcohols and their acetates

Details

Serval ID
serval:BIB_12979
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Rat model for renal effects of 2-alkoxyalcohols and their acetates
Journal
Archives of Toxicology
Author(s)
Liesivuori J., Laitinen J., Savolainen H.
ISSN
0340-5761
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
73
Number
4-5
Pages
229-232
Language
english
Abstract
Male Wistar rats were given ethanediol (9.4 g/l), 2-ethoxyethylacetate (5.4 g/l), 2-butoxyethylacetate (2.9 g/l) and 1,2-propanediol (40 g/l) respectively in their drinking water for 2 weeks. Urine was collected during the last 24 h of the exposure. There was a marked increase in the oxalic acid excretion by the rats given ethanediol while rats given the alkoxyacetates excreted large amounts of ethoxyacetic and butoxyacetic acid, respectively. While not increased compared with controls, the excretion of oxalic acid by the latter group of rats was correlated to the excretion of the respective alkoxyacetic acids. The ammonia and glycosaminoglycan excretion was also smaller than that of controls. The urinary activity of succinate dehydrogenase was decreased in rats given the alkoxyacetates but not in animals exposed to ethanediol or propanediol. The data show that oxalic acid is actually a minor metabolite of the alkoxyacetates while the biochemical effects in kidney are associated more with the alkoxyacetic acid load. Alkoxyacetic acids seem to be inhibitors of renal succinate dehydrogenase, which may account for the decreased ammonia and glycosaminoglycan excretion.
Keywords
Acetates/pharmacology, Acetic Acids/urine, Alcohols/pharmacology, Animals, Enzyme Inhibitors/pharmacology, Ethylene Glycols/pharmacology, Glycolates/urine, Kidney/drug effects, Oxalic Acid/urine, Propylene Glycol/pharmacology, Rats, Rats, Wistar, Reducing Agents/analysis, Succinate Dehydrogenase/metabolism, Succinate Dehydrogenase/urine, Urine/chemistry, Water
Pubmed
Web of science
Create date
19/11/2007 12:04
Last modification date
20/08/2019 12:40
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