Characterizing evoked hemodynamics with fMRI.

Details

Serval ID
serval:BIB_1285E7BF4458
Type
Article: article from journal or magazin.
Collection
Publications
Title
Characterizing evoked hemodynamics with fMRI.
Journal
Neuroimage
Author(s)
Friston K.J., Frith C.D., Turner R., Frackowiak R.S.
ISSN
1053-8119 (Print)
ISSN-L
1053-8119
Publication state
Published
Issued date
1995
Volume
2
Number
2
Pages
157-165
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
We describe an implementation of the general linear model that facilitates the characterization of evoked hemodynamic responses to sensorimotor or cognitive processing, when the exact form of these responses is not known. The importance of this approach is that one can test for differential responses among tasks that may elude more conventional analyses. In particular, we suppose that an evoked response has early and late components and that a differential response may involve (i) both components to the same degree, as in a conventional "activation" or (ii) differential expression of the early and late components in two tasks, as might be seen in differential adaptation, or differences associated with the tasks (e.g., requiring and not requiring sustained attention). Using this approach we were able to demonstrate that the anterior cingulate differentiates, in terms of its response, between two motor tasks that did and did not require sustained attention. This differential response was observed even though there was no classical "activation" (i.e., there was no difference in the mean activity associated with the two conditions). It is suggested that these demonstration results point to the possibility of making greater use of the temporal resolution afforded by fast fMRI techniques.
Keywords
Arousal/physiology, Attention/physiology, Brain/blood supply, Brain Mapping/instrumentation, Functional Laterality/physiology, Gyrus Cinguli/blood supply, Hemodynamics/physiology, Humans, Image Processing, Computer-Assisted/instrumentation, Linear Models, Magnetic Resonance Imaging/instrumentation, Motor Cortex/blood supply, Somatosensory Cortex/blood supply
Pubmed
Web of science
Create date
16/09/2011 19:48
Last modification date
20/08/2019 12:40
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