Deterioration of renal function in hypertensive patients with scleroderma despite blood pressure normalization with captopril.

Details

Serval ID
serval:BIB_12810A7FAFDE
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Deterioration of renal function in hypertensive patients with scleroderma despite blood pressure normalization with captopril.
Journal
Klinische Wochenschrift
Author(s)
Waeber B., Schaller M.D., Wauters J.P., Brunner H.R.
ISSN
0023-2173 (Print)
ISSN-L
0023-2173
Publication state
Published
Issued date
1984
Volume
62
Number
15
Pages
728-730
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The orally active angiotensin-converting enzyme inhibitor captopril was administered for up to 11 weeks to three patients with progressive systemic sclerosis presenting with hypertension and plasma creatinine levels of 3.1, 7.2 and 10.4 mg/100 ml. Only one patient had malignant phase hypertension. In this patient a diuretic had to be added to captopril in order to keep blood pressure under control. Despite sustained blood pressure control during captopril administration, renal function deteriorated and hemodialysis treatment had to be started in all patients. Up to that time no substantial improvement in skin lesions was observed. During the period of dialysis, blood pressure was normal in all patients even though administration of captopril was discontinued. All three patients died of respiratory failure while on chronic hemodialysis for 3 to 4 weeks. These observations confirm that angiotensin-converting enzyme inhibition may be helpful in controlling blood pressure of patients with scleroderma. However, in contrast to some earlier reports, they also indicate that converting enzyme inhibition does not always prevent the multivisceral vascular lesions of scleroderma.
Keywords
Acute Kidney Injury/etiology, Aged, Blood Pressure/drug effects, Captopril/adverse effects, Captopril/therapeutic use, Female, Humans, Hypertension/complications, Hypertension/drug therapy, Male, Middle Aged, Proline/analogs & derivatives, Scleroderma, Systemic/complications
Pubmed
Web of science
Create date
06/09/2011 17:15
Last modification date
20/08/2019 12:40
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