Spot urine samples for evaluating solute excretion in the first week of life.

Details

Serval ID
serval:BIB_12758
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Spot urine samples for evaluating solute excretion in the first week of life.
Journal
Archives of Disease in Childhood. Fetal and Neonatal Edition
Author(s)
Matos V., Drukker A., Guignard J.P.
ISSN
1359-2998
Publication state
Published
Issued date
1999
Volume
80
Number
3
Pages
240-242
Language
english
Abstract
AIM: To evaluate whether the urinary creatinine concentration is a reliable reference value to standardise urinary solute excretion in a spot urine sample during the first week of life. METHODS: Spontaneously voided urine specimens were obtained in 48 healthy, full term neonates, aged 1 to 6 days (median 2.4) and in 168 healthy older children with a median age of 1.5 years (range 1 month to 3 years). In 62% of the children two urine samples were available with an interval of 2 to 4 (neonates) and 7 days (older children). RESULTS: In neonates both the urinary creatinine concentration and the urinary creatinine:osmolality ratios were significantly higher than in the older children, and were spread over a wider range. During the first postnatal week of life the mean urinary creatinine and urinary creatinine: osmolality ratio values in the first urine samples were also significantly higher than in the second samples. In children aged between 1 month and 3 years of age, these data were remarkably stable without any significant changes between repeat urine samples. CONCLUSIONS: The urinary creatinine concentration during the first days of life is high and variable, even when corrected for urinary osmolality. This is the opposite of what is found in older children and adults. Urinary creatinine and the urinary creatinine:osmolality ratio, therefore, cannot be used to standardise the urinary excretion of solutes in the first week of life.
Keywords
Biological Markers/urine, Child, Preschool, Creatinine/urine, Humans, Infant, Infant, Newborn, Kidney/physiology, Osmolar Concentration, Predictive Value of Tests, Reference Standards
Pubmed
Web of science
Create date
19/11/2007 12:04
Last modification date
20/08/2019 12:40
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