Compliance with aspirin or placebo in the Hypertension Optimal Treatment (HOT) study.

Details

Serval ID
serval:BIB_12709
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Compliance with aspirin or placebo in the Hypertension Optimal Treatment (HOT) study.
Journal
Journal of Hypertension
Author(s)
Waeber B., Leonetti G., Kolloch R., McInnes G.T.
ISSN
0263-6352 (Print)
ISSN-L
0263-6352
Publication state
Published
Issued date
1999
Volume
17
Number
7
Pages
1041-1045
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
OBJECTIVE: The Hypertension Optimal Treatment (HOT) study is a large, prospective trial aimed at defining the level of diastolic blood pressure required during anti-hypertensive therapy in order to achieve maximal protection against cardiovascular complications. A further aim is to assess the effects on morbidity and mortality of a 75 mg daily dose of aspirin compared with placebo.
SUBJECTS AND METHODS: Compliance with double-blind administration of aspirin or placebo added to anti-hypertensive treatment was evaluated for 1 year in a subset (n = 530) of the study population (n = 18 790) by placing the medication in a container closed with an electronic cap that records precisely the time of each opening.
RESULTS: The 1-year compliance rate (percentage of days with one opening per day) could be assessed in 501 patients. It averaged 78.3 +/- 25% in aspirin-treated patients (n = 236, mean +/- SD), compared with 78.5 +/- 25% in patients having received placebo (n = 265), and was not influenced by age, sex or country (Germany, Italy, Switzerland, UK). The compliance rate was also similar irrespective of whether the patients had reached their target blood pressure, but was significantly better during the first than the second 6-month monitoring period (84.1 +/- 22% versus 72.3 +/- 32%, n = 501).
CONCLUSIONS: The high rate of compliance with aspirin or placebo observed in the HOT study suggests that the patients were highly motivated and may account for the unusually good blood pressure control achieved in this trial during long-term anti-hypertensive treatment.
Keywords
Aged, Antihypertensive Agents/administration & dosage, Aspirin/administration & dosage, Blood Pressure/drug effects, Female, Fibrinolytic Agents/administration & dosage, Humans, Hypertension/drug therapy, Hypertension/physiopathology, Male, Middle Aged, Patient Compliance
Pubmed
Web of science
Create date
19/11/2007 12:04
Last modification date
20/08/2019 12:40
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