Host innate immune responses to microbial pathogens.

Details

Serval ID
serval:BIB_126E45EAABE8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Host innate immune responses to microbial pathogens.
Journal
Current Vascular Pharmacology
Author(s)
Delaloye J., Calandra T.
ISSN
1875-6212 (Electronic)
ISSN-L
1570-1611
Publication state
Published
Issued date
2013
Volume
11
Number
2
Pages
123-132
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Sepsis is among the leading causes of death worldwide and its incidence is increasing. Defined as the host response to infection, sepsis is a clinical syndrome considered to be the expression of a dysregulated immune reaction induced by danger signals that may lead to organ failure and death. Remarkable progresses have been made in our understanding of the molecular basis of host defenses in recent years. The host defense response is initiated by innate immune sensors of danger signals designated under the collective name of pattern-recognition receptors. Members of the family of microbial sensors include the complement system, the Toll-like receptors, the nucleotide-binding oligomerization domainlike receptors, the RIG-I-like helicases and the C-type lectin receptors. Ligand-activated pattern-recognition receptors kick off a cascade of intracellular events resulting in the expression of co-stimulatory molecules and release of effector molecules playing a fundamental role in the initiation of the innate and adaptive immune responses. Fine tuning of proinflammatory and anti-inflammatory reactions is critical for keeping the innate immune response in check. Overwhelming or dysregulated responses induced by infectious stimuli may have dramatic consequences for the host as shown by the profound derangements observed in sepsis. Unfortunately, translational research approaches aimed at the development of therapies targeting newly identified innate immune pathways have not held their promises. Indeed, all recent clinical investigations of adjunctive anti-sepsis treatments had little, if any, impact on morbidity and all-cause mortality of sepsis. Dissecting the mechanisms underlying the transition from infection to sepsis is essential for solving the sepsis enigma. Important components of the puzzle have already been identified, but the hunt must go on in the laboratory and at the bedside.
Pubmed
Web of science
Create date
13/06/2013 17:25
Last modification date
20/08/2019 12:40
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