Fractionated irradiation combined with carbogen breathing and nicotinamide of two human glioblastomas grafted in nude mice

Details

Serval ID
serval:BIB_125D750912BB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fractionated irradiation combined with carbogen breathing and nicotinamide of two human glioblastomas grafted in nude mice
Journal
Radiation Research
Author(s)
Sun  L. Q., Coucke  P. A., Mirimanoff  R. O., Buchegger  F.
ISSN
0033-7587 (Print)
Publication state
Published
Issued date
01/2001
Volume
155
Number
1 Pt 1
Pages
26-31
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
This study addressed the potential radiosensitizing effect of nicotinamide and/or carbogen on human glioblastoma xenografts in nude mice. U-87MG and LN-Z308 tumors were irradiated with either 20 fractions over 12 days or 5 fractions over 5 days in air-breathing mice, mice injected with nicotinamide, mice breathing carbogen, or mice receiving nicotinamide plus carbogen. The responses to treatment were assessed using local control and moist desquamation. In U-87MG tumors, the enhancement ratios (ERs) at the radiation dose required to produce local tumor control in 50% of the treated mice (TCD(50)) with nicotinamide and/or carbogen ranged from 1.13 to 1.24 for irradiation in 20 fractions over 12 days. In LN-Z308 tumors, the ERs at the TCD(50) with nicotinamide and/or carbogen ranged from 1.22 to 1.40 for irradiation in 5 fractions over 5 days and from 1.11 to 1.30 in 20 fractions over 12 days, respectively. Skin injury was slightly enhanced, with ERs ranged from 1.06 to 1.15 when radiation was combined with carbogen and/or nicotinamide. Thus carbogen and nicotinamide can slightly improve the radiation response of human glioblastoma xenografts.
Keywords
Administration, Inhalation Animals Brain Neoplasms/drug therapy/pathology/*radiotherapy Carbon Dioxide/administration & dosage/*pharmacology Cell Division/drug effects/radiation effects Combined Modality Therapy Dose Fractionation Drug Therapy, Combination Female Glioblastoma/drug therapy/pathology/*radiotherapy Humans Mice Mice, Nude Niacinamide/*pharmacology Oxygen/administration & dosage/*pharmacology Radiation Injuries, Experimental/etiology Radiation-Sensitizing Agents/administration & dosage/*pharmacology Skin/drug effects/radiation effects Tumor Cells, Cultured Xenograft Model Antitumor Assays
Pubmed
Web of science
Create date
24/01/2008 17:12
Last modification date
20/08/2019 12:40
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