Pulmonary infiltrates in patients with haematologic malignancies: transbronchial lung biopsy increases the diagnostic yield with respect to neoplastic infiltrates and toxic pneumonitis.
Details
Serval ID
serval:BIB_124B707B015C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pulmonary infiltrates in patients with haematologic malignancies: transbronchial lung biopsy increases the diagnostic yield with respect to neoplastic infiltrates and toxic pneumonitis.
Journal
Annals of hematology
ISSN
0939-5555 (Print)
ISSN-L
0939-5555
Publication state
Published
Issued date
07/2004
Peer-reviewed
Oui
Volume
83
Number
7
Pages
420-422
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
We retrospectively evaluated 107 fiberoptic bronchoscopies with and without transbronchial lung biopsy (TBLB) in 98 consecutive patients with haematologic malignancies and pulmonary infiltrates. Bronchoalveolar lavage (BAL) was performed in 45 and BAL plus TBLB in 62 procedures. There was no procedure-related severe haemorrhage, pneumothorax or death. Infectious aetiology was identified in 26 of 107 (24%), toxic pneumonitis in 17 of 107 (16%) and neoplastic infiltration in 9 of 107 (8.5%) episodes. Combined BAL and TBLB was significantly superior to BAL alone with respect to the diagnosis of neoplastic infiltrates (p=0.008) and toxic pneumonitis (p<0.001) and should therefore be included in the diagnostic work-up of this patient cohort.
Keywords
Adult, Aged, Antineoplastic Agents/adverse effects, Biopsy/adverse effects, Biopsy/methods, Biopsy/statistics & numerical data, Bronchoalveolar Lavage Fluid, Bronchoscopy, Cohort Studies, Disease Progression, Female, Fiber Optic Technology, Hematologic Neoplasms/complications, Hematologic Neoplasms/diagnosis, Hematologic Neoplasms/pathology, Hemorrhage/etiology, Hemorrhage/prevention & control, Humans, Leukemic Infiltration, Lung/pathology, Lung Diseases/diagnosis, Lung Diseases/etiology, Lung Diseases/pathology, Male, Middle Aged, Myelodysplastic Syndromes/complications, Myelodysplastic Syndromes/diagnosis, Myelodysplastic Syndromes/pathology, Platelet Transfusion, Pneumonia/chemically induced, Pneumonia/diagnosis, Pneumonia/etiology, Pneumonia/pathology, Predictive Value of Tests, Retrospective Studies
Pubmed
Web of science
Create date
02/12/2024 17:50
Last modification date
04/12/2024 8:07
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