Identifying Neural Signatures Mediating Behavioral Symptoms and Psychosis Onset: High-dimensional Whole Brain Functional Mediation Analysis.

Details

Ressource 1Download: Chén et al (2021).pdf (1776.76 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_124B55E56570
Type
Article: article from journal or magazin.
Collection
Publications
Title
Identifying Neural Signatures Mediating Behavioral Symptoms and Psychosis Onset: High-dimensional Whole Brain Functional Mediation Analysis.
Journal
NeuroImage
Author(s)
Chén Oliver Y, Cao Hengyi, Phan Huy, Nagels Guy, Reinen Jenna M, Gou Jiangtao, Qian Tianchen, Di Junrui, Prince John, Cannon Tyrone D, de Vos Maarten
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Publication state
Published
Issued date
01/02/2021
Peer-reviewed
Oui
Volume
226
Pages
117508
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Along the pathway from behavioral symptoms to the development of psychotic disorders sits the multivariate mediating brain. The functional organization and structural topography of large-scale multivariate neural mediators among patients with brain disorders, however, are not well understood. Here, we design a high-dimensional brain-wide functional mediation framework to investigate brain regions that intermediate between baseline behavioral symptoms and future conversion to full psychosis among individuals at clinical high risk (CHR). Using resting-state functional magnetic resonance imaging (fMRI) data from 263 CHR subjects, we extract an α brain atlas and a β brain atlas: the former underlines brain areas associated with prodromal symptoms and the latter highlights brain areas associated with disease onset. In parallel, we identify and separate mediators that potentially positively and negatively mediate symptoms and psychosis, respectively, and quantify the effect of each neural mediator on disease development. Taken together, these results paint a brain-wide picture of neural markers that are potentially mediating behavioral symptoms and the development of psychotic disorders; additionally, they underscore a statistical framework that is useful to uncover large-scale intermediating variables in a regulatory biological system.
Keywords
Behavioral Symptoms/diagnostic imaging, Behavioral Symptoms/physiopathology, Brain/diagnostic imaging, Brain/physiopathology, Brain Mapping/methods, Female, Humans, Image Interpretation, Computer-Assisted/methods, Magnetic Resonance Imaging/methods, Male, Mediation Analysis, Prodromal Symptoms, Psychotic Disorders/diagnostic imaging, Psychotic Disorders/physiopathology, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2024 19:05
Last modification date
18/01/2024 16:22
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