Growth and pubertal development in five boys with Noonan's syndrome

Details

Serval ID
serval:BIB_124B4DF46953
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Growth and pubertal development in five boys with Noonan's syndrome
Journal
Archives of Disease in Childhood
Author(s)
Theintz  G., Savage  M. O.
ISSN
1468-2044 (Electronic)
Publication state
Published
Issued date
01/1982
Volume
57
Number
1
Pages
13-7
Notes
Journal Article --- Old month value: Jan
Abstract
Five boys, each with at least 4 features characteristic of Noonan's syndrome, were studied throughout childhood. In each the height was on or below the 3rd centile. Height velocity was essentially normal during the prepubertal period whereas bone age and pubertal development were delayed. Four boys had cryptorchidism and in 2 no testicular enlargement or spontaneous puberty occurred, necessitating testosterone replacement. Plasma concentrations of luteinising hormone and follicle-stimulating hormone before and after stimulation with luteinising hormone-releasing hormone were increased in 4 of the boys. These findings are consistent with primary gonadal failure associated with impaired spermatogenesis.
Keywords
Adolescent Child Cryptorchidism/complications Follicle Stimulating Hormone/blood *Growth Humans Luteinizing Hormone/blood Male Noonan Syndrome/complications/*physiopathology *Puberty Testis/physiopathology Testosterone/blood
Pubmed
Web of science
Create date
25/01/2008 10:30
Last modification date
20/08/2019 12:40
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