Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor.

Details

Ressource 1Download: serval:BIB_12415A079C40.P001 (711.14 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_12415A079C40
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor.
Journal
International Immunology
Author(s)
Voelter V., Rufer N., Reynard S., Greub G., Brookes R., Guillaume P., Grosjean F., Fagerberg T., Michielin O., Rowland-Jones S., Pinilla C., Leyvraz S., Romero P., Appay V.
ISSN
1460-2377
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
20
Number
8
Pages
1087-1096
Language
english
Notes
Publication types: Journal Article
Abstract
Melan-A specific CD8+ T cells are thought to play an important role against the development of melanoma. Their in vivo expansion is often observed with advanced disease. In recent years, low levels of Melan-A reactive CD8+ T cells have also been found in HLA-A2 healthy donors, but these cells harbor naive characteristics and are thought to be mostly cross-reactive for the Melan-A antigen. Here, we report on a large population of CD8+ T cells reactive for the Melan-A antigen, identified in one donor with no evidence of melanoma. Interestingly, this population is oligoclonal and displays a clear memory phenotype. However, a detailed study of these cells indicated that they are unlikely to be directly specific for melanoma, so that their in vivo expansion may have been driven by an exogenous antigen. Screening of a Melan-A cross-reactive peptide library suggested that these cells may be specific for an epitope derived from a Mycobacterium protein, which would provide a further example of CD8+ T cell cross-reactivity between a pathogen antigen and a tumor antigen. Finally, we discuss potential perspectives regarding the role of such cells in heterologous immunity, by influencing the balance between protective immunity and pathology, e.g. in the case of melanoma development.
Pubmed
Web of science
Open Access
Yes
Create date
11/03/2009 14:02
Last modification date
25/09/2019 6:08
Usage data