Performance of 18F-FDG PET/CT in Selecting Thyroid Nodules with Indeterminate Fine-Needle Aspiration Cytology for Surgery. A Systematic Review and a Meta-Analysis.

Details

Serval ID
serval:BIB_1222709B9449
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Performance of 18F-FDG PET/CT in Selecting Thyroid Nodules with Indeterminate Fine-Needle Aspiration Cytology for Surgery. A Systematic Review and a Meta-Analysis.
Journal
Journal of clinical medicine
Author(s)
Castellana M., Trimboli P., Piccardo A., Giovanella L., Treglia G.
ISSN
2077-0383 (Print)
ISSN-L
2077-0383
Publication state
Published
Issued date
28/08/2019
Peer-reviewed
Oui
Volume
8
Number
9
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Thyroid nodules with indeterminate fine-needle aspiration cytology (FNA) represent a major challenge in clinical practice. We conducted a systematic review and meta-analysis evaluating the ability of hybrid imaging using fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ( <sup>18</sup> F-FDG PET/CT) to appropriately select these nodules for surgery. PubMed, CENTRAL, Scopus, and Web of Science were searched until July 2019. Original articles reporting data on the performance of <sup>18</sup> F-FDG PET/CT in thyroid nodules with indeterminate FNA were included. Summary operating points including 95% confidence interval values (95% CI) were estimated using a random-effects model. Out of 786 retrieved papers, eight studies evaluating 104 malignant and 327 benign thyroid nodules were included. The pooled positive and negative likelihood ratios (LR+ and LR-) and diagnostic odds ratio (DOR) of <sup>18</sup> F-FDG PET/CT were 1.7 (95% CI: 1.4-2.0), 0.4 (95% CI: 0.2-0.7), and 3.5 (95% CI: 1.7-7.1), respectively. No heterogeneity was found for LR+ and DOR. In patients with thyroid nodules with indeterminate FNA, <sup>18</sup> F-FDG PET/CT has a moderate ability to correctly discriminate malignant from benign lesions and could represent a reliable option to reduce unnecessary diagnostic surgeries. However, further studies using standardized criteria for interpretation are needed to confirm the reproducibility of these findings.
Keywords
FDG, PET/CT, diagnostic performance, meta-analysis, systematic review, thyroid nodule
Pubmed
Web of science
Open Access
Yes
Create date
17/09/2019 15:49
Last modification date
12/03/2020 6:26
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