Expression of CD28 and CD38 by CD8+ T lymphocytes in HIV-1 infection correlates with markers of disease severity and changes towards normalization under treatment. The Swiss HIV Cohort Study.

Details

Serval ID
serval:BIB_12088
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Expression of CD28 and CD38 by CD8+ T lymphocytes in HIV-1 infection correlates with markers of disease severity and changes towards normalization under treatment. The Swiss HIV Cohort Study.
Journal
Clinical and Experimental Immunology
Author(s)
Bürgisser P., Hammann C., Kaufmann D., Battegay M., Rutschmann O.T.
ISSN
0009-9104
Publication state
Published
Issued date
1999
Volume
115
Number
3
Pages
458-463
Language
english
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The relationship between blood CD8+ T lymphocyte subsets, as defined by CD28 and CD38 expression, and plasma viraemia and CD4+ T cells in HIV-1 infection was investigated. In a cross-sectional study of 46 patients with either no or stable anti-retroviral treatment, there was a strong negative correlation between the percentage of CD8+CD28- and the percentage of CD4+ T cells (r = -0.75, P < 0.0001), and a positive correlation between absolute numbers of CD8+CD28+ and CD4+ T cells (r = 0.56, P < 0.0001). In contrast, the expression of CD38 by CD8+ T lymphocytes correlated primarily with plasma viraemia (e.g. the percentage of CD38+ in CD8bright cells, r = 0.76, P < 0.0001). In the 6 months following triple therapy initiation in 32 subjects, there was a close correlation between changes (delta) in CD8+CD28+ or CD8+CD28- and in CD4+ T cells (e.g. delta % CD8+CD28+ versus delta % CD4+, r = 0.37, P = 0.0002; delta % CD8+CD28- versus delta % CD4+, r = -0.66, P < 0.0001). A marked decline of the number of CD8+ T cells expressing CD38 was also observed. These results suggest the existence of a T cell homeostasis mechanism operating in blood with CD4+ and CD8+CD28+ cells on the one hand, and with CD8+CD28- cells on the other. In addition, the percentage of CD38+ cells in CD8+ cells, generally considered an independent prognostic factor, could merely reflect plasma viral load.
Keywords
ADP-ribosyl Cyclase, Anti-HIV Agents/therapeutic use, Antigens, CD, Antigens, CD28/metabolism, Antigens, CD38, Antigens, Differentiation/metabolism, Biological Markers, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Cohort Studies, Cross-Sectional Studies, HIV Infections/drug therapy, HIV Infections/immunology, HIV-1, Homeostasis, Humans, Membrane Glycoproteins, NAD+ Nucleosidase/metabolism, Prognosis, Switzerland, T-Lymphocyte Subsets/immunology, Viremia/immunology
Pubmed
Web of science
Create date
19/11/2007 13:02
Last modification date
20/08/2019 13:39
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