CD73 expression and clinical significance in human metastatic melanoma.

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State: Public
Version: Final published version
Serval ID
serval:BIB_11E2460193C6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CD73 expression and clinical significance in human metastatic melanoma.
Journal
Oncotarget
Author(s)
Monteiro I., Vigano S., Faouzi M., Treilleux I., Michielin O., Ménétrier-Caux C., Caux C., Romero P., de Leval L.
ISSN
1949-2553 (Electronic)
ISSN-L
1949-2553
Publication state
Published
Issued date
01/06/2018
Peer-reviewed
Oui
Volume
9
Number
42
Pages
26659-26669
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
CD73 is an ectoenzyme involved in the production of adenosine. It exerts immunosuppressive and protumoral roles and has emerged as a potential immuno-oncology target.
CD73 expression was detected in TC in 54% of melanoma metastases, involving < 50% TC in the majority of the cases, with variable intensity. CD73 expression was significantly associated with a lower Breslow's depth of the primary lesion and was more frequent in patients having received prior non-surgical therapies. In an adjusted analysis, CD73 expression in TC (H-score > 37.5 or intensity > 1) significantly correlated to decreased overall survival (OS) from biopsy. Of the samples containing TIMC, 35% presented CD73+ TIMC. Highly infiltrated tumors were more likely to contain CD73+ TIMC. CD73 expression in TIMC (percentage ≥1%) significantly correlated with improved OS from biopsy.
Immunohistochemistry detected CD73 expression in more than half of metastatic melanomas. While CD73 expression in TC significantly correlated with decreased OS, CD73 expression in TIMC significantly associated with improved OS. These results encourage the study of anti-CD73 therapies for metastatic melanoma patients.
CD73 expression was assessed by immunohistochemistry in metastatic melanomas from 114 patients. Immunostainings were evaluated in tumor cells (TC) (percentage, intensity (1-3) and H-score) and in tumor-infiltrating mononuclear cells (TIMC) (percentage).
Keywords
CD73, ecto-5'-nucleotidase, immunohistochemistry, melanoma, prognosis
Pubmed
Open Access
Yes
Create date
26/06/2018 9:10
Last modification date
20/08/2019 13:39
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