Place de la microfecondation dans les echecs repetes de fecondation in vitro: le role des parametres feminins. [Value of microfertilization for repeated in vitro fertilization failures: the role of female parameters]

Details

Serval ID
serval:BIB_11E07ACED9B8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Place de la microfecondation dans les echecs repetes de fecondation in vitro: le role des parametres feminins. [Value of microfertilization for repeated in vitro fertilization failures: the role of female parameters]
Journal
Contracept Fertil Sex
Author(s)
Fanchin  R., Wolff  J. P., de Ziegler  D., Lelaidier  C., Hazout  A., Frydman  R.
ISSN
1165-1083
Publication state
Published
Issued date
02/1993
Volume
21
Number
2
Pages
153-6
Notes
Clinical Trial
Comparative Study
English Abstract
Journal Article --- Old month value: Feb
Abstract
Microfertilization technics as SUZI (sub-zonal insemination) can be indicated in cases of repeated in vitro fertilization (IVF) failure. Feminine parameters seem to play however an important role in optimalization of results. We studied 27 couples (32 IVF-SUZI cycles) who had previously presented 2 to 4 in vitro fertilization failures. These 32 cycles were divided in 2 groups according to women's age: group A < or = 35 and group B > 35 years. Results: basal FSH levels were higher in group B (6.6 +/- 3.1 mIU/ml) in comparison to group A (3.7 +/- 1.5 mIU/ml). The amount of hMG necessary to accomplish ovarian stimulation was also higher in group B (39 +/- 21 ampules) than in group A (26 +/- 11 ampules). Maximal plasma estradiol levels were higher in group A (2,775 +/- 872 pg/ml) than in group B (1,824 +/- 559 pg/ml) such as the mean number of oocytes collected and micro-injected: 11.6 +/- 4.5 versus 4.7 +/- 2.2 in groups A and B, respectively. Eight pregnancies (44%), of which 7 were ongoing pregnancies, were obtained in group A. No pregnancy was obtained in group B. Conclusions: SUZI seems to be an available technic for treatment of repeated IVF failures; our results seem to indicate a decrease in SUZI results with age of the women (> 35 years old); they suggest the opportunity of a complete investigation of feminine parameters prior to each SUZI-IVF cycle.
Keywords
Estradiol/blood Female *Fertilization in Vitro Follicle Stimulating Hormone/blood Humans Infertility/blood/epidemiology/*therapy Insemination, Artificial/*methods *Maternal Age Menotropins/therapeutic use Micromanipulation/*methods Ovulation Induction/methods Pregnancy Pregnancy Outcome *Pregnancy, High-Risk Prognosis Sex Factors Treatment Failure *Zona Pellucida
Pubmed
Web of science
Create date
28/02/2008 11:36
Last modification date
20/08/2019 12:39
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