The inflammasomes.

Details

Serval ID
serval:BIB_11D73169535B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The inflammasomes.
Journal
Cell
Author(s)
Schroder K., Tschopp J.
ISSN
1097-4172[electronic], 0092-8674[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
140
Number
6
Pages
821-832
Language
english
Abstract
Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1beta to engage innate immune defenses. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway in tailoring immune responses. Here, we comprehensively review mechanisms directing normal inflammasome function and its dysregulation in disease. Agonists and activation mechanisms of the NLRP1, NLRP3, IPAF, and AIM2 inflammasomes are discussed. Regulatory mechanisms that potentiate or limit inflammasome activation are examined, as well as emerging links between the inflammasome and pyroptosis and autophagy.
Keywords
Adaptor Proteins, Signal Transducing/immunology, Animals, Caspases/metabolism, Humans, Inflammation/immunology, Inflammation/metabolism, Interleukins/metabolism, Organelles/immunology, Receptors, Pattern Recognition/immunology
Pubmed
Web of science
Open Access
Yes
Create date
07/09/2010 15:30
Last modification date
20/08/2019 12:39
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