Prophylactic oophorectomy.

Details

Serval ID
serval:BIB_11A9BB8735C1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Prophylactic oophorectomy.
Journal
Best Practice and Research. Clinical Obstetrics and Gynaecology
Author(s)
Coukos G., Rubin S.C.
ISSN
1521-6934 (Print)
ISSN-L
1521-6934
Publication state
Published
Issued date
2002
Volume
16
Number
4
Pages
597-609
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
Because of the lack of effective alternatives and the simplicity of the procedure, prophylactic oophorectomy is viewed as the best available tool for reducing the individual risk of ovarian cancer. The genetics of hereditary ovarian cancer are described in this chapter and a careful risk-versus-benefit assessment is provided with respect to two populations of patients that appear suitable candidates for this procedure. These include patients with increased risk of developing ovarian cancer due to hereditary genetic predisposition, in which the lifetime risk of ovarian cancer may be as high as 16-65%, depending on the penetrance of the germ-line mutation. Additionally, routine salpingo-oophorectomy in patients over 40 years undergoing scheduled gynaecological surgery or colorectal surgery might reduce the overall incidence of ovarian cancer by as much as 5% in the general population.
Keywords
Female, Genes, Tumor Suppressor, Humans, Neoplastic Syndromes, Hereditary/genetics, Neoplastic Syndromes, Hereditary/prevention & control, Ovarian Neoplasms/genetics, Ovarian Neoplasms/prevention & control, Ovariectomy, Risk Assessment
Pubmed
Create date
14/10/2014 12:43
Last modification date
20/08/2019 13:39
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