Increased plasticity of the stiffness of melanoma cells correlates with their acquisition of metastatic properties.

Details

Serval ID
serval:BIB_1145BA9CFDD9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increased plasticity of the stiffness of melanoma cells correlates with their acquisition of metastatic properties.
Journal
Nanomedicine
Author(s)
Weder G., Hendriks-Balk M.C., Smajda R., Rimoldi D., Liley M., Heinzelmann H., Meister A., Mariotti A.
ISSN
1549-9642 (Electronic)
ISSN-L
1549-9634
Publication state
Published
Issued date
2014
Volume
10
Number
1
Pages
141-148
Language
english
Abstract
The stiffness of tumor cells varies during cancer progression. In particular, metastatic carcinoma cells analyzed by Atomic Force Microscopy (AFM) appear softer than non-invasive and normal cells. Here we examined by AFM how the stiffness of melanoma cells varies during progression from non-invasive Radial Growth Phase (RGP) to invasive Vertical Growth Phase (VGP) and to metastatic tumors. We show that transformation of melanocytes to RGP and to VGP cells is characterized by decreased cell stiffness. However, further progression to metastatic melanoma is accompanied by increased cell stiffness and the acquisition of higher plasticity by tumor cells, which is manifested by their ability to greatly augment or reduce their stiffness in response to diverse adhesion conditions. We conclude that increased plasticity, rather than decreased stiffness as suggested for other tumor types, is a marker of melanoma malignancy. These findings advise caution about the potential use of AFM for melanoma diagnosis.
FROM THE CLINICAL EDITOR: This study investigates the changes to cellular stiffness in metastatic melanoma cells examined via atomic force microscopy. The results demonstrate that increased plasticity is a marker of melanoma malignancy, as opposed to decreased stiffness.
Pubmed
Web of science
Create date
24/01/2014 18:21
Last modification date
20/08/2019 12:38
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